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KMID : 0363220080460060826
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Korean Journal of Dermatology
2008 Volume.46 No. 6 p.826 ~ p.830
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A Case of Xanthoma Disseminatum with Diabetes Insipidus
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Choi Gyu-Won
Lee Chae-Young
Lee Yeong-Kyu
Kim Hong-Seok
Lee Chae-Wook
Kim Ki-Ho
Kim Young-Hun
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Abstract
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Xanthoma disseminatum (XD) is a rare, potentially progressive non-Langerhans cell histiocytosis, which preferentially
affects males in their childhood or young adulthood. It is characterized by the insidious onset of small, yellowish-red to brown papules and nodules that are discrete and disseminated. They characteristically involve the eyelids and flexural areas of the axillary and inguinal folds, and the antecubital and popliteal fossae. Systemic disease frequently occurs, the most common manifestation being diabetes insipidus (DI), which occurs in about 40% of cases and is due to deposition of xanthoma cells in the hypothalamic-pituitary axis. We present a case of XD with DI, which was treated with the combination therapy of CO2 laser vaporization, cyclophosphamide, electrocauterization and synthetic antidiuretic hormone. (Korean J Dermatol 2008;46(6):826∼830)
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KEYWORD
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Diabetes insipidus, Xanthoma disseminatum
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